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KMID : 0369819920220020125
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Jorunal of Korean Pharmaceutical Sciences
1992 Volume.22 No. 2 p.125 ~ p.131
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Effects of Domperidone , Scopolamine Butylbromide and Cimetidine on Absorption and Bioavailability of Ciprofloxacin in Rats
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임혜숙/Yim HS
박기배/이도익/이광표/Park GB/Lee DI/Lee KP
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Abstract
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The effects of domperidone, scopolamine butylbromide and cimetidine on the absorption and bioavailability of ciprofloxacin were studied in female rats. Ciprofloxacin was given in a single oral dose of 30 mg/kg to control group. Ciprofloxacin was concurrently administered with domperidone $(T_1\;group)$ 수식 이미지, scopolamine butylbromide $(T_2\;group)$ 수식 이미지, and cimetidine $(T_3\;group)$ 수식 이미지 to rats, respectively. Significantly changed pharmacokinetic parameters observed in $T_2$ 수식 이미지group when compared with control group were first-order absorption rate constant, $Ka(4.43{\pm}0.85$\;versus\;2.86{\pm}0.41\;hr^{-1},\;p<0.05)$ 수식 이미지, time needed to reach peak concentration, $T_{max}\;(32.27{\pm}2.46\;versus\;51.75{\pm}5.51\;min,\;p<0.05)$ 수식 이미지, area under the plasma concentration-time curve, AUC $(332{\pm}19\;versus\;477{\pm}27\;{\mu}g{\cdot}min/ml,\;p<0.05)$ 수식 이미지 and absolute bioavailability, Fabs $(60.6{\pm}3.6\;versus\;87.0{\pm}5.0%,\;p<0.05)$ 수식 이미지. On the other hand, domperidone and cimetidine did not significantly affect the absorption of ciprofloxacin. It is suggested that when scopolamine butylbromide is selected for clinical use, there is need for awareness of the reduction in absorption rate and the enhancement in absorption extent of ciprofloxacin.
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KEYWORD
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Domperidone, scopolamine butylbromide, cimetidine, ciprofloxacin, absorption, bioavailability
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